ACE inhibitors confer greater protection against coronary heart disease than angiotensin receptor blockers, according to a major Australian review.A meta-analysis of 26 major trials that involved either an ACE inhibitor or angiotensin receptor blocker as one treatment arm found each class provided comparable blood pressure reduction, which correlated with reductions in risk of stroke, CHD and heart failure.But ACE inhibitors provided an additional 9% relative risk reduction in CHD, even in the absence of blood pressure reduction an effect not seen with angiotensin receptor blockers, researchers found.These findings therefore suggest that the coronary disease prevention afforded by a blood pressure-lowering regimen may be determined by the choice of agent as well as the size of the blood pressure reduction...
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