BMJ Aspirin resistance, thought to affect up to one-third of patients, is associated with significantly increased cardiovascular morbidity, a comprehensive meta-analysis suggests.The research, which analysed 20 studies including 2930 patients with cardiovascular disease, found aspirin-resistant patients had an almost sixfold increase in risk of death, were almost four times more likely to experience a cardiovascular event, and were at more than four times greater risk of acute coronary syndrome compared with non-resistant patients.An accompanying editorial in the BMJ(online, 18 January) speculated on whether aspirin resistance represented a truly abnormal response to the drug or whether it reflects normal variability in drug activity”Professor Phil Harris, head of cardiology at Sydneys Royal Prince Alfred Hospital, said the latest data suggested research...
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